Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm
نویسندگان
چکیده
منابع مشابه
Acute exacerbation of idiopathic pulmonary fibrosis: shifting the paradigm.
The goal of this review is to summarise the clinical features, management, and prognosis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). AE-IPF has previously been defined based on clinical and radiological features that include the subacute onset of dyspnoea, bilateral ground glass changes on chest high-resolution computed tomography, and the absence of an identifiable aetiol...
متن کاملAcute exacerbation of idiopathic pulmonary fibrosis.
BACKGROUND The clinical course of patients with idiopathic pulmonary fibrosis (IPF) is generally marked by a decline in pulmonary function over time. Increasingly, patients have been recognized as having an acute, and often fatal, clinical deterioration, termed an acute exacerbation of IPF (AE-IPF). METHODS Review of the current literature pertaining to AE-IPF. RESULTS Acute exacerbations a...
متن کاملAcute exacerbation of idiopathic pulmonary fibrosis: report of a series.
This study describes five cases presenting an acute clinical course of pulmonary fibrosis, in the absence of specific precipitating factors. A retrospective chart review of five patients with histologically proved usual interstitial pneumonia was carried out in 2001-2002. Clinical data, bronchoalveolar lavage (BAL) findings, high resolution computed tomography and histological features were rep...
متن کاملMacrophage Activation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
BACKGROUND Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a common cause of disease acceleration in IPF and has a major impact on mortality. The role of macrophage activation in AE of IPF has never been addressed before. METHODS We evaluated BAL cell cytokine profiles and BAL differential cell counts in 71 IPF patients w/wo AE and in 20 healthy volunteers. Twelve patients s...
متن کاملPlasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
Little is known about the pathobiology of acute exacerbation of idiopathic pulmonary fibrosis (IPF), a condition that shares clinical and histopathological features with acute lung injury. Plasma biomarkers have been well studied in acute lung injury and have provided insight into the underlying disease mechanism. The objective of this study was to determine the plasma biomarker profile of acut...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2015
ISSN: 0903-1936,1399-3003
DOI: 10.1183/13993003.00419-2015